All seminars are at 2:15 in Room 2041, Building 37, unless otherwise indicated

September

4 Prasun J. Mishra (Laboratory of Cancer Biology & Genetics, Earl Stadtman Tenure-track Investigator candidate)
Integrated Genomics and microRNAomics of Melanomagenesis: From Novel Targets to
Therapeutic Opportunities

11 Oscar Cheng, Research Fellow, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH (guest of Kandice Tanner)

Store-Operated Ca2+ Entry: From Physiological to Pathophysiological Functions

18 Lisa Jenkins, Collaborative Protein Technology Resource, LCB

Ejecting the Metal: The Use of Mass Spectrometry to Elucidate the Mechanism of HIV Zinc Finger Inhibitors

25

October

2  Jan Johansson, Karolinska Institute, Stockholm, Sweden (guest of Ettore Appella)

BRICHOS Domains and Amyloid β-Peptide Fibrillation: A New Route Toward Alzheimer’s Disease Therapy

9  No seminar--NIH Research Festival

16 Yang Zhang, Staff Scientist, Biochemistry of Proteins Section, LCB

Human ClpP Contributes to Cisplatin Resistance

23 Balazs Sarkadi, Semmelweis University and National Blood Center, Budapest, Hungary (guest of Michael Gottesman)

The ABCG2 Protein as a Multifaceted Transporter - From Substrates to Regulation

30

November

6 Frank J. Gonzalez, Laboratory of Metabolism, CCR, NCI (guest of Suresh Ambudkar)

Metabolomics in the CCR

13  Annual research ethics training

20 Robert Tycko, National Institute of Diabetes and Digestive and Kidney Diseases, NIH (guest of Kandice Tanner)

Insights Into Amyloid Structure from Solid State NMR

27 

December

4 Doron Levy, Department of Mathematics, University of Maryland, College Park (guest of Michael Gottesman)

Mathematical Models of Leukemia, Cancer Stem Cells, and Drug Resistance

11 Jean-Pierre Gillet, Staff Scientist, Multidrug Resistance Section, LCB

Multidrug Resistance Transcriptome Analysis Highlights Compounds That Sensitize Resistant Hepatocellular Carcinoma Through Increased Histone Acetylation

18 
           
25 No seminar--Christmas

January

8 Matt Humbard, Biochemistry of Proteins Section, LCB

Identification of N-End Rule Substrates

15 Justin Taraska, Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, NIH (guest of Suresh Ambudkar)

Imaging the Nanometer-Scale Architecture of Vesicle Release and Recapture

22 Sharlyn Mazur, Staff Scientist, Chemical Immunology Section, LCB

Essential Characteristics of the Wip1 Phosphatase

29 Stewart Durell, Molecular Modeling Core, LCB

Structural Basis for Regulation of p53 by N-terminal Phosphorylation

February

5

12 Lothar Esser, Staff Scientist, Crystallography Section, LCB

Conformational Flexibility of Proteins:  Use of Anomalous Signals in Detecting Domain Motions in bc1 and Aspects of Intrinsic Flexibility and Asymmetry of P-gp

19 Susannah Gal, Department of Biological Sciences, Binghamton University, Binghamton, NY (guest of Michael Gottesman)

Differences in the Regulation of the Human Tumor Suppressor p53

26 Munira Basrai, Genetics Branch, CCR (guest of Michael Gottesman)

Determinants of Faithful Chromosome Transmission in Budding Yeast and its Human Homologs

March

5 Clare Waterman, Director, Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, NIH (guest of Kandice Tanner) in Room 4041

Myosin II Minimizes Membrane Curvature to Guide Endothielial Cell Branching Morphogenesis

12 Suneet Shukla, Staff Scientist, Transport Biochemistry Section, LCB

Identification of the Tyrosine Kinase Inhibitor Nilotinib Binding Site on P-glycoprotein: Use of 3D-QSAR, Molecular Modeling and Mutational Mapping Approaches

19 Kan Tanoue, Chemical Immunology Section, LCB

The Third and Catalytically Essential Metal Ion of the Human Phosphatases PP2Calpha and Wip1

26 Reinhard Grisshammer, National Institute of Neurological Disorders and Stroke (guest of Di Xia)

Structure of the Agonist-Bound Neurotensin Receptor NTS1

April

2 Eshel Ben-Jacob, Sackler School of Physics and Astronomy and The Sagol School of Neuroscience,
Tel Aviv University, Israel (guest of Kandice Tanner)

From Social Intelligence of Bacteria to Cyber-war on Cancer 

9 No seminar—AACR annual meeting, Washington, DC

16 Yong-Yu Liu, University of Louisiana at Monroe, Department of Basic Pharmaceutical Sciences (guest of Suresh Ambudkar)

Role of Ceramide Glycosylation in Cancer Drug Resistance

23 Julio Valencia, Staff Scientist, Pigment Cell Research Section, LCB

The Heart and Core of Pigmentation Reveal Clues to Melanoma Invasion, Proliferation and Drug Resistance

30 Jacqueline Milne, 3D Electron Microscopy and Image Processing Core, LCB

Emerging Frontiers in 3D Electron Microscopy

May

7 Wilfred Stein, Medical Oncology Branch, NCI (guest of Michael Gottesman)

How Analyzing the Time Course of a Tumor's Decay and Regrowth Under Drug Treatment Can be a Guide to Therapy

14 Alberto Bartesaghi, Biophysics Section, LCB

New Computational Tools and Automation Strategies for Cryo-Electron Microscopy

21 Rui Bao, Crystallography Section, LCB

Structure Studies of Chaperone/Usher Pili in Pathogenic Enterobacteriaceae: Implications in Host Cell Binding and Pili Assembling Mechanism

28 Kenneth Kraemer, Chief, DNA Repair Section, Dermatology Branch, NCI (guest of Vince Hearing)

June

4 Alan Weissman (guest of Mike Maurizi)

11 Hiroyasu Sakai, Chemical Immunology Section, LCB

18 Stanley Lipkowitz, Laboratory of Cellular and Molecular Biology, NCI (guest of Mike Maurizi)

25 Lawrence Samelson, Chief, Laboratory of Cellular and Molecular Biology and Deputy Director, Center for Cancer Research (guest of Michael Gottesman)